Absin: Trusted in 17,000+ Papers—Your Hard-Core Partner for Research Breakthroughs

Case 1: IF 52.7 Signal Transduction and Targeted Therapy — Breaking the Blood–Brain Barrier, Reshaping Alzheimer’s Therapy

Journal: Signal Transduction and Targeted Therapy (IF = 52.7, portal link: https://www.absin.cn/article-2346.html, DOI traceable)

Pain-point: Aβ plaques in Alzheimer’s are hard to clear; BBB dysfunction accelerates pathology.

Solution: 7-Color multiplex IHC kit (abs50031) delivers high-sensitivity detection of low-abundance targets, enables four-colour simultaneous labelling and signal amplification, clearly showing LRP1 relocation and Aβ deposition.

Outcome: A nano-therapy that repairs BBB transport lowered brain Aβ by 45 % and durably improved cognition in AD mice, offering a brand-new paradigm.

Case 2: IF 52.7 Signal Transduction and Targeted Therapy — Overcoming Liver-Cancer Immune Resistance, Opening New Combo-Therapy Avenues

Journal: Signal Transduction and Targeted Therapy (IF = 52.7, portal link: https://www.absin.cn/article-2243.html, DOI traceable)

Pain-point: High resistance rate to immune-checkpoint inhibitors in HCC; T-cell exhaustion keeps tumours “cold”.

Solution: Hanks’ balanced salt solution (abs9257) served as the digestion buffer, maintaining osmotic pressure and pH to generate high-activity single-cell suspensions for flow-cytometry analysis of T-cell infiltration.

Outcome: Unveiled a lipid-metabolism reprogramming mechanism of resistance; GalNAc-siTACC3 plus anti-PD-1 markedly suppressed tumour growth and prolonged mouse survival, providing a new HCC strategy.

Case 3: IF 48.5 Nature — Decoding the Human Sweet-Taste Receptor, Powering Next-Gen Sweetener Design

Journal: Nature (IF = 48.5, portal link: https://www.absin.cn/article-2196.html, DOI traceable)

Pain-point: 3-D structure of the human sweet receptor (TAS1R2-TAS1R3) was unknown, hindering mechanistic studies and sweetener development.

Solution: Anti-TAS1R2 antibody (abs139799) specifically recognises human TAS1R2, produces a single clear band in WB with no cross-reactivity, and accurately validates recombinant receptor expression and purification.

Outcome: First high-resolution structure of the sweet receptor revealed ligand-binding and signal-transduction mechanisms, supplying a molecular basis for treating metabolic diseases and designing new sweeteners.

Case 4: IF 42.5 Cell — Small-Molecule-Induced Embryo Model Rewrites the Rules of Developmental Biology

Journal: Cell (IF = 42.5, portal link: https://www.absin.cn/article-2344.html, DOI traceable)

Pain-point: Traditional embryo models rely on transgenics or mixed culture, yielding low fidelity and efficiency, and fail to recapitulate organogenesis.

Solution: Bovine serum albumin (abs9156) was used to prepare blocking buffer for immunostaining, occupying non-specific sites and ensuring precise localization of Oct4/CDX2/GATA6 markers for reliable lineage identification.

Outcome: High-fidelity embryo model recapitulated key organogenesis stages with 73.53 % chimeric efficiency, providing a revolutionary tool for developmental studies and drug screening.

17,000+ citations are recognition—and merely our starting line. Guided by “quality above promise”, Absin backs every experiment with traceable top-journal data and reliable reagents. Choose Absin today for top-tier quality and exclusive rewards, and let us earn a place in the Materials & Methods of your next high-impact paper!