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Arbidol Hydrochloride
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Arbitol hydrochloride (AH) is chemically named 6-bromo-4 - (dimethylamino-methyl) -5-hydroxy-1-methyl-2 - (phenylthiophenyl) -1H-indole-3-carboxylic acid ethyl ester hydrochloride, where hydrochloric acid is used as a stabilizer for Arbitol, CAS number 131707-23-8, The molecular formula is C22H25BrN2O3S•HCl, and the molecular weight is 531.90. It is mainly used for the prevention and treatment of influenza A and B and other respiratory virus infections. It has the advantages of oral convenience, high safety, good compliance and no cytotoxicity, and has a wide application prospect.
The COVID-19 in Wuhan affected everyone's mind. Fortunately, with the whole country working together, the epidemic has been effectively controlled. On February 19, the sixth edition of the Novel Coronavirus Pneumonia Diagnosis and Treatment Protocol (Trial) was released, which also shows that we have more standardized protocols and approaches in the face of this new infectious disease. The sixth version includes two "new" drugs, chloroquine phosphate and arbitol.
Chloroquine phosphate, an older drug used to treat malaria and autoimmune diseases, blocks viral infection by increasing the endosomal pH required for viral/cell fusion. In addition to antiviral activity, chloroquine also has immunomodulatory activity, which can synergistically enhance its strong antiviral effect.
The inclusion of Arbidor has been controversial.Arbidol is an antiviral drug, developed by the former Soviet Union medical Chemistry research center, the main indications are A class A, B influenza virus caused by influenza, at the same time, some other respiratory virus infection may also have antiviral activity, with broad-spectrum antiviral characteristics.
Arbidol inhibits the fusion of virus and host cell membrane, and is an antiviral drug with HA as the receptor. Hemagglutinin is mainly found in influenza viruses, so arbidol has A good therapeutic effect on influenza A and B, while the HA protein is not present on the Novel Coronavirus, which means that the mechanism by which Arbidol blocks the entry of the virus into the human cell membrane may not be valid.
The research of Li Lanjuan, an academician of the Chinese Academy of Engineering, and his team showed that in vitro cell experiments: Arbidol at 10-30 micromol concentration, compared with the untreated control group, can effectively inhibit the coronavirus up to 60 times, and significantly inhibit the pathological effect of the virus on cells.
The problem of this in vitro cell experimental study is that the concentration of 10-30 micromol is much higher than the tolerance of human body, which is difficult to achieve in human body, and there is still a gap between in vitro experiment and clinical practice. In addition to Remdesivir "People's Hope", other important clinical trials of NCOVCOVID-19 are currently under way, such as lopinavir combined with Ritonavir and arbiol in the treatment of Novel coronavirus infection, led by Professor Linghua Li from Guangzhou No. 8 People's Hospital. More clinical and basic research may be needed to explore some of the controversies surrounding Arbidor. Absin biotech provides a comprehensive range of agonist inhibitor products to help scientists with related research, high-quality spot, high cost performance, large specifications and more attractive prices.
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March 24, 2022
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