Why are some people allergic to fish?Some people are allergic to fish, as long as the consumption of a little fish, it is possible to have a rash, itchy skin and other allergic phenomena, where is the problem?

Because they lack an enzyme that breaks down histamine in fish;Once histamine is absorbed by the body and enters the immune system, it can cause allergies.Most people have enzymes that break down histamine, so they don't have allergies.It is worth noting that ingestion of more histamine than the body can tolerate can lead to anaphylaxis.

Histamine receptor
Histamine is an active amine compound.It causes a wide range of cellular reactions, including allergies, inflammation and stomach acid secretion, and can affect nerve conduction in the brain.

There are three subtypes of histamine receptors in the body: H1, H2 and H3. Most of the H1 receptors are distributed in capillaries, bronchus and intestinal smooth muscle. When H1 receptors are activated, they can cause allergic urticaria, pruritus accompanied by vascular nerve edema, laryngospasm and bronchospasm.H2 receptor is mainly distributed in gastric parietal cells and vascular smooth muscle cells, which can promote gastric acid secretion and telangiectasia.The role of the H3 receptor is still being studied.

Receptor	Organization	Effect
H1	Bronchial, gastrointestinal, uterus and other smooth muscles	shrink
	Skin heart	Expand
	Atrium, Atrioventricular node	Contraction increases and conduction slows
H2	Parietal cell	Secretion increased
	Blood vessel	Expand
	Atrium, Atrioventricular node	The contraction intensifies and the heart rate increases
H3	CNS and peripherals	Negative feedback regulates histamine
	Nerve endings	Synthesis and release

 

Cat#	Name	Size
abs818405	ABT-239	10mg/5mg
abs814456	Acrivastine	25mg/100mg/10mg/50mg
abs817558	Alcaftadine	10mg/50mg/100mg
abs813486	Antazoline hydrochloride	100mg
abs813517	Betahistine dihydrochloride	100mg/200mg/1g
abs813532	Buclizine hydrochloride	100mg/500mg
abs816499	Cetirizine dihydrochloride	50mg/100mg/200mg
abs816325	Chlorpheniramine Maleate	50mg/100mg/200mg/1g
abs813592	Desloratadine	25mg/50mg/100mg/200mg
abs817306	Famotidine	10mg/50mg/25mg/100mg
abs813146	GSK-189254A	5mg/10mg/50mg/100mg
abs816982	Histamine	10mg/50mg/100mg
abs813672	Histamine dihydrochloride	100mg/500mg
abs813105	JNJ-39758979	5mg/10mg
abs813689	JNJ-7777120	10mg/50mg/100mg/5mg
abs819186	Mianserin	100mg/200mg
abs813427	Mianserin hydrochloride	100mg/200mg/50mg
abs818406	Pitolisant	50mg/10mg
abs816681	Promethazine hydrochloride	100mg/50mg/200mg/500mg
abs814469	S 38093	5mg/10mg
abs816950	Stugeron	25mg/100mg/200mg/50mg
abs813871	Tripelennamine hydrochloride	25mg/50mg/100mg/200mg